The team struggles with the news that Warehouse 13 will be moving to a new host country.
Valda tries to move the warehouse to China and use Claudia’s comatose sister as a puppet caretaker.
Pete, Myka and Artie help Pete’s ex-girlfriend track an object that sucks them all into a Telenovela.
Pete and Steve search for an artifact that makes a horseless chariot and a life-size chess piece come to life; Claudia combines artifacts in a desperate attempt to revive her sister.
Myka and Pete encounter two secret service agents that force them to question their own relationship, while Artie attempts to show Claudia the truth about her sister.
When Paracelsus takes control of Warehouse 13, it proves to only be the first step in his plan to recreate the entire world in his image. To stop him, Pete and Myka must follow him back through time to 1541 and prevent him from killing the Regents and becoming the permanent master of the Warehouses.
Pete and Myka capture Paracelsus but not before he makes himself immortal. When Myka’s cancer becomes worse, Pete must make a deal with Paracelsus to cure his partner. Meanwhile, Claudia receives some startling news from Artie.
Pete, Myka, and Charlotte must track down Sutton, the only man who knows where they can find Paracelsus and exchange the Philosopher’s Stone for the stele that will free Claudia from her bronze imprisonment… before she disintegrates.
The agents track down a cache of artifacts stolen from Warehouse 12 by the infamous Roaring Dan Seavey… and guarded by his ghost. Meanwhile, Charlotte Dupres makes her move with the help of her inside person.
Someone in a gated community is using an artifact to extract vengeance and Myka and Pete go to investigate. Meanwhile, Artie and Claudia help a teen suffering from dangerous visions, and Steve and Abigail clean up the Warehouse.